Radiobiological Meta-Analysis of the Response of Prostate Cancer to High-Dose-Rate Brachytherapy: Investigation of the Reduction in Control for Extreme Hypofractionation.

ABSTRACT:

Background/objectives

Clinical studies have shown a marked reduction in tumor control in prostate cancer treated with radically hypofractionated high-dose-rate brachytherapy (HDR-BT). The purpose of this study was to analyze the dose-response of prostate cancer treated with HDR-BT, specifically aiming at investigating the potential failure of the linear-quadratic (LQ) model to describe the response at large doses-per-fraction.

Methods

We collated a dataset of dose-response to HDR-BT (3239 patients). The analysis was conducted separately for low and intermediate risk, resulting in 21 schedules (1633 patients) and 23 schedules (1606 patients), respectively. Data were fitted to tumor control probability models based on the LQ model, the linear-quadratic-linear (LQL), and a modi

SUBMITTER: Kolmel EG 

PROVIDER: S-EPMC12025418 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature