Single-Cell Profiling Reveals Global Immune Responses During the Progression of Murine Epidermal Neoplasms.

ABSTRACT:

Background/objectives

Immune cells determine the role of the tumor microenvironment during tumor progression, either suppressing tumor formation or promoting tumorigenesis. This study aimed to fully characterize immune cell responses during skin tumor progression.

Methods

Using single-cell RNA sequencing, we analyzed the profile of immune cells in the tumor microenvironment of control mouse skins and skin tumors at the single-cell level.

Results

We identified 15 CD45⁺ immune cell clusters, which broadly represent the most functionally characterized immune cell types including macrophages, Langerhans cells (LC), conventional type 1 dendritic cells (cDC1), conventional type 2 dendritic cells (cDC2), migratory/mature dendritic cells (mDC), dendritic epidermal

SUBMITTER: Fan X 

PROVIDER: S-EPMC12025564 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature