Exploring the Evolution-Coupling Hypothesis: Do Enzymes' Performance Gains Correlate with Increased Dissipation?

ABSTRACT: The research literature presents divergent opinions regarding the role of dissipation in living systems, with views ranging from it being useless to it being essential for driving life. The implications of universal thermodynamic evolution are often overlooked or considered controversial. A higher rate of entropy production indicates faster thermodynamic evolution. We calculated enzyme-associated dissipation under steady-state conditions using minimalistic models of enzyme kinetics when all microscopic rate constants are known. We found that dissipation is roughly proportional to the turnover number, and a log-log power-law relationship exists between dissipation and the catalytic efficiency of enzymes. "Perfect" specialized enzymes exhibit the highest dissipation levels and represent the

SUBMITTER: Juretic D 

PROVIDER: S-EPMC12025749 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature