Longitudinal Trajectories of Cognitive Function Among Chinese Middle-Aged and Older Adults: The Role of Sarcopenia and Depressive Symptoms.

ABSTRACT: Objectives: The longitudinal relationship between sarcopenia, depression, and cognitive impairment has been insufficiently studied in China. This study aimed to characterize the association between sarcopenia and cognitive impairment and the mediating role of depression using nationally representative data. Methods: 7091 middle-aged and older adults were analyzed from the China Health and Retirement Longitudinal Study (CHARLS) across three waves (2011, 2013, and 2015). Cognitive trajectories were modeled using a group-based trajectory model (GBTM), while multivariable ordinal logistic regression was employed to evaluate the associations with cognitive trajectories. The mediating role of depressive symptoms was assessed through bootstrap mediation analysis and cross-lagged pan

SUBMITTER: Jin S 

PROVIDER: S-EPMC12025789 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature