Comparison of ERlangen Score with pTau/Aβ1-42 Ratio for Predicting Cognitive Decline and Conversion to Alzheimer's Disease.

ABSTRACT: Background/Objectives: The ERlangen Score (ERS) and the pTau/Aβ1-42 ratio are dementia risk scores that use only surrogate markers of amyloid and tau pathology, whose performance has taken on added importance with the advent of anti-amyloid antibody therapies. Direct comparisons between the scores are limited, which is why the performance of the ERlangen Score (ERS) and the pTau/Aβ1-42 ratio in predicting cognitive decline and dementia risk were compared. Methods: Measurements of Aβ1-42, Aβ1-40, and pTau181 were conducted in cerebrospinal fluid samples using immunoassays. Linear mixed models and the area under the receiver operating characteristic curve (AUC, receiver operating characteristic = ROC) of 259 non-demented subjects were calculated. Results: The pTau/Aβ1-42

SUBMITTER: Schwarz JA 

PROVIDER: S-EPMC12026031 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature