Insight into the role of DNA methylation in prognosis and treatment response prediction of gastrointestinal cancers.

ABSTRACT: Gastrointestinal (GI) cancers impose a significant disease burden, underscoring the critical importance of accurate prognosis prediction and treatment response evaluation. DNA methylation, one of the most extensively studied epigenetic modifications, has gained prominence due to its reliable measurement across various sample types. Numerous studies have reported that DNA methylation was linked to the diagnosis, prognosis and treatment response in malignancies, including GI cancers. While its diagnostic role in GI cancers has been comprehensively reviewed. Recent research has increasingly highlighted its potential in prognosis prediction and treatment response evaluation. However, no existing reviews have exclusively focused on these two aspects. In this review, we retrieved relevant studie

SUBMITTER: Reyila A 

PROVIDER: S-EPMC12026041 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature