Nephroprotective Effects of <i>Tanacetum balsamita</i> Extract on Metabolic-Induced Renal Injury (MIRI) in Rats.

ABSTRACT: The progression of type 2 diabetes is associated with multiple complications, one of which is diabetic nephropathy (DN). This study aimed at investigating the nephroprotective potential of two doses 150 mg/kg and 300 mg/kg of Tanacetum balsamita leaf extract (ETB) on metabolic-induced renal injury (MIRI) in rats. Markers of renal oxidative stress and antioxidant defense, histopathology, serum biochemistry, and urinalysis were measured. Blood glucose level and arterial blood pressure were assessed weekly for the experimental period of eight weeks. ETB at a high dose significantly decreased the blood glucose levels and mildly lowered systolic pressure in diabetic rats. In the kidney, ETB restored the antioxidant marker malondialdehyde, reduced glutathione, and markedly increased enzym

SUBMITTER: Simeonova R 

PROVIDER: S-EPMC12026245 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature