Oncogene-Induced Senescence Transcriptomes Signify Premalignant Colorectal Adenomas.

ABSTRACT: Background: Oncogene-induced senescence (OIS) is a tumor-suppressive mechanism that halts uncontrolled cell proliferation in premalignant lesions. Further investigation into its role in colorectal tumorigenesis is essential. We investigated the expression of OIS transcriptomic landscapes in premalignant colorectal adenomas and whether their resolution is part to adenoma-to-carcinoma progression. Methods: Using a publicly available gene expression dataset (GSE117606), we analyzed 66 paired (matched) adenoma-adenocarcinoma samples. Single-sample gene set enrichment analysis (ssGSEA) was performed to assess OIS and senescence-associated secretory phenotype (SASP) signatures, and differential gene expression analysis was conducted to examine key senescence-related genes. Resul

SUBMITTER: Al Shboul S 

PROVIDER: S-EPMC12026309 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature