Temperature- and pH-Responsive Poly(NIPAM-<i>co</i>-HEMA-<i>co</i>-AAm) Nanogel as a Smart Vehicle for Doxorubicin Delivery; Combating Colorectal Cancer.

ABSTRACT: In this project, a new class of temperature- and pH-sensitive hydrogel consisting of N-isopropyl acrylamide (NIPAM), hydroxyethyl methacrylate (HEMA), and acrylamide (AAm) was prepared via a controlled route through the reversible addition-fragmentation chain-transfer (RAFT) polymerization process. Poly(ethyleneglycol) dimethacrylate (PEG-DMA) was used as a long-chain hydrophilic and biocompatible crosslinking agent. The hydrogel structure was confirmed by different characteristic techniques such as ¹H NMR, FT-IR, and SEC, and the morphology and particle diameters were checked via the scanning electron microscopy (SEM) and dynamic light scattering (DLS) methods. Afterward, the as-prepared hydrogel, poly(NIPAM-co-HEMA-co-AAm), was loaded with doxorubicin (DOX

SUBMITTER: Ghasemi S 

PROVIDER: S-EPMC12026571 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature