Preparation and Characterization of Vitamin D3-Based Binary Amorphous Systems.

ABSTRACT: Vitamin D3 (VD3) is an essential nutrient for human health that plays a key role in bone health and immune regulation. However, VD3 deficiency has become a common issue worldwide due to insufficient daily intake and inadequate conversion from sunlight exposure. The relatively poor aqueous solubility of VD3 is one of the major challenges in the development of oral supplements and functional foods, since it usually results in low oral absorption. In this study, a total of 11 potential binary systems were prepared by solvent evaporation. The binary amorphous system of VD3 and L-arginine (ARG) has been found to be the most promising binary system, since the VD3-ARG system can significantly improve the solubility of VD3, with an 80-fold enhancement relative to neat crystalline VD3. The amorphiz

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12026574 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature