CIT tumor lines: A novel series of immunogenic cutaneous squamous cell carcinoma cell lines derived from chemical carcinogenesis.

ABSTRACT: Immunotherapy is now widely used to treat advanced-stage skin cancer, but it is effective for only approximately half of skin cancer patients, including both patients with melanoma and cutaneous squamous cell carcinoma (cSCC). To overcome current barriers, preclinical mouse models that faithfully recapitulate the tumor genetics, mutation burdens, and neoantigen patterns of specific human tumor types are essential. However, while many models exist for melanoma, there are currently relatively few transplantable murine models of cSCC, which is responsible for nearly as many deaths as melanoma each year. Here we describe a novel series of 11 cSCC tumor lines, the Carcinogen-Induced Tumor (CIT) lines, syngeneic to the FVB strain, that address this need. The CIT lines were established from skin

SUBMITTER: Letchworth R 

PROVIDER: S-EPMC12026586 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature