Sickle Cell Disease and Antimicrobial Resistance: A Systematic Review and Meta-Analysis.

ABSTRACT: Background/Objectives: Antimicrobial resistance (AMR) is increasingly rising due to antimicrobial overuse and misuse. In sickle cell disease (SCD) care, frequent antibiotic use drives the rapid emergence of AMR, threatening treatment options and patient lives. This systematic review synthesizes data on AMR with regard to SCD patients for the first time. Methods: A comprehensive database search for articles published in English was conducted in PubMed, Scopus, ScienceDirect, and Web of Science, with no restriction set for the year of publication. The DerSimonian-Laird method was applied to derive the pooled prevalence, while the Mantel-Haenszel method was used to calculate the pooled odds ratio. Results: A total of 18 eligible studies covering 3220 SCD patients publishe

SUBMITTER: Opoku-Asare B 

PROVIDER: S-EPMC12026643 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature