Differences in Plasma Lactoferrin Concentrations Between Subjects with Normal Cognitive Function and Mild Cognitive Impairment: An Observational Study.

ABSTRACT:

Background

Previous studies suggested that decreased saliva lactoferrin (LF) levels might be used to differentiate subjects with mild cognitive impairment (MCI) from subjects with normal cognitive function (NCF). Here, we aimed to assess differences in plasma LF concentrations between subjects with NCF and MCI.

Methods

In total, 113 NCF subjects and 113 MCI individuals were included in this study. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale, and anthropometric parameters, body composition, physical activity, cardio-metabolic parameters, and LF levels were measured.

Results

MCI subjects had significantly lower LF levels than NCF participants (p < 0.0001). There were also significant differences between the study groups in

SUBMITTER: Jamka M 

PROVIDER: S-EPMC12026691 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature