Bioinformatic Analysis of Autism-Related miRNAs and Their PoTential as Biomarkers for Autism Epigenetic Inheritance.

ABSTRACT:

Background/objectives

The dysregulation of miRNA expression in samples from autistic individuals indicates that they are involved in autism. The participation of miRNAs in paternal epigenetic inheritance has also been reported. This study used bioinformatics tools to analyze the literature and genetic databases to search for miRNAs associated with autism, aiming to explore their suitability to investigate paternal epigenetic inheritance.

Methods

Autism-related miRNAs were searched in public databases using bioinformatic tools (miRNA-to-genes analysis). The genes targeted by these autism-related miRNAs, which are common to neurons, sperm, and PBMCs, were identified. Enrichment analyses were performed to identify the biological processes regulated by the candidate miRNAs. Auti

SUBMITTER: Acerbi da Silva LN 

PROVIDER: S-EPMC12026732 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature