Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of <i>ortho</i>-Tyrosines.

ABSTRACT: Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a growing class of natural products that possess many activities that are of potential translational interest. Multinuclear non-heme iron dependent oxidative enzymes (MNIOs), until recently termed domain of unknown function 692 (DUF692), have been gaining interest because of their involvement in a range of biochemical reactions that are remarkable from a chemical perspective. Over 13,500 putative MNIO-encoding biosynthetic gene clusters (BGCs) have been identified by sequence similarity networks (SSNs). In this study, we identified a set of precursor peptides containing a conserved FHAFRF-motif in MNIO-encoding BGCs. These BGCs follow a conserved synteny with genes encoding an MNIO, a RiPP recognition element (RR

SUBMITTER: Padhi C 

PROVIDER: S-EPMC12026744 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature