Measures of Homozygosity and Relationship to Genetic Diversity in the Bearded Collie Breed.

ABSTRACT: Background: Genetic diversity in closed populations, such as pedigree dogs, is of concern for maintaining the health and vitality of the population in the face of evolving challenges. Measures of genetic diversity rely upon estimates of homozygosity without consideration of whether the homozygosity is desirable or undesirable or if heterozygosity has a functional impact. Pedigree coefficients of inbreeding have been the classical approach yet they are inadequate unless based upon the entire population. Methods: Homozygosity measures based upon pedigree analyses (n = 11,898), SNP array data (n = 244), and whole genome sequencing (n = 23) were compared in the Bearded Collie, as well as a comparison of SNP array data to a pedigree cohort (n = 5042) an

SUBMITTER: Belanger JM 

PROVIDER: S-EPMC12026756 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature