Transcription factor hubs exhibit gene-specific properties that tune expression.

ABSTRACT: The spatial and temporal control of gene expression relies on transcription factors binding to and occupying their target sites. Transcription factor hubs-localized, high-concentration microenvironments-promote transcription by facilitating binding and recruitment of transcriptional machinery and co-factors. Hubs are often thought to have emergent nucleus-wide properties depending on transcription factor nuclear concentrations and intrinsic, protein sequence-dependent properties. This global model does not account for gene-specific hub regulation. Using high-resolution lattice light-sheet microscopy in Drosophila embryos, we examined hubs formed by the morphogen transcription factor, Dorsal, at reporter genes with distinct enhancer compositions. We found that snail recruits l

SUBMITTER: Fallacaro S 

PROVIDER: S-EPMC12026892 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature