Establishment of a Novel Platform for Developing Oral Vaccines Based on the Surface Display System of Yeast Spores.

ABSTRACT: Oral vaccines are currently the focus of vaccine development because they are convenient to administer, easy to distribute, and capable of activating mucosal immunity. However, the complexity of the gastrointestinal environment and the lack of delivery vehicles severely limit the stability and effectiveness of oral vaccines. This study established a novel platform for developing oral vaccines based on the surface display system of yeast spores. As a specific example, oral vaccines for COVID-19, designed by displaying the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein on the surface of three Saccharomyces cerevisiae spore types, including AN120, osw2Δ, and dit1Δ, were constructed and evaluated. The displayed RBD showed perfect gastrointestinal stability i

SUBMITTER: Si C 

PROVIDER: S-EPMC12026953 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature