Preparation of pH-Sensitive Poly (N-(2-Hydroxyethyl) Acrylamide-co-acrylic Acid) Hydrogels and Their Performance.

ABSTRACT: Drug-loaded hydrogels are promising for modern medicine due to their physical modifiability. However, most hydrogels suffer from poor swelling, which limits their drug encapsulation and release capabilities. In this study, Poly (N-(2-hydroxyethyl) acrylamide-co-acrylic acid) (Poly (HEAA-co-AA)) hydrogels with high swelling properties are synthesized via free radical polymerization of neutralized acrylic monomers. The effects of the material ratio and acrylic acid neutralization degree on the swelling properties of hydrogels in water are investigated, and the swelling properties of hydrogels prepared with different monomer ratios in different pH buffer solutions are systematically studied. The results show that the swelling degree is sensitive to the monomer ratio and pH. The maximum equili

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12027044 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature