Stimuli-Responsive Hydrogels of Poly(Methacrylic Acid)/Poly(N,N-dimethylacrylamide) Interpenetrating Polymer Networks as Drug Delivery Systems for Promethazine Hydrochloride.

ABSTRACT: Hydrogels with tunable properties are of great interest for the development of advanced drug delivery systems. In this study, novel hydrogels with an interpenetrating polymer network (IPN) structure were obtained from the pH-responsive poly(methacrylic acid) (PMAA) and the neutral poly(N,N-dimethylacrylamide) (PDMAM). The newly synthesized IPN hydrogels were shown to be pH responsive with a 1.5 to 2.5 fold increase in their equilibrium swelling ratio at a pH above 5 which makes them appropriate for targeted intestine drug delivery. Moreover, their pH responsiveness was found to be strongly influenced by the IPN's composition. The IPN hydrogels were loaded with PMH via swelling and the drug entrapment efficiency was found to depend on their swelling characteristic varying with the IPN's com

SUBMITTER: Simeonov M 

PROVIDER: S-EPMC12027187 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature