Unpacking KDIGO Guidelines: Prioritizing and Applying Exposures and Susceptibilities for AKI in Clinical Practice.

ABSTRACT: Background/Objectives: Acute kidney injury (AKI) is a significant global health issue with a high morbidity and mortality. The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines identify various exposures and susceptibilities as risk factors for AKI. However, the predictive significance of these factors in heterogeneous emergency department (ED) populations remains unclear. We hypothesized that assessing KDIGO-listed exposures and susceptibilities for AKI, alone and in combination, would provide an insight into their predictive value for AKI. Furthermore, we investigated whether adding biomarkers, plasma neutrophil gelatinase-associated lipocalin (pNGAL) and C-reactive protein (CRP), could enhance AKI risk prediction. Methods: Data were analyzed from the prospective

SUBMITTER: Wetterstrand VJR 

PROVIDER: S-EPMC12027667 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature