The Effectiveness of Low-Density Lipoprotein/Fibrinogen Apheresis in Promoting Wound Healing of No-Option Chronic Limb-Threatening Ischemia Foot Ulcers with Wound, Ischemia, and Foot Infection (WIfI) Wound Grade 3: A Single-Center Retrospective Analysis.

ABSTRACT: Background: Chronic limb-threatening ischemia (CLTI) is a severe condition associated with high mortality and amputation rates, particularly in patients with diabetes, renal failure, or severe vascular disease. In cases where revascularization fails or is not possible, adjunctive therapies can improve the treatment outcomes. Therefore, this single-center retrospective study aimed to evaluate the effectiveness of low-density lipoprotein/fibrinogen apheresis (Rheocarna^®) in promoting wound healing in patients with no-option CLTI, focusing on large wounds. Methods: We examined the data of 32 CLTI ulcers treated with Rheocarna^® from 2021 to 2024. Results: The outcomes in 25 cases (78.1%) were rated as excellent or good, and the outcomes of 11 (73.3%)

SUBMITTER: Fujii M 

PROVIDER: S-EPMC12027775 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature