Cardiotoxicity Associated with Venlafaxine-Defining Features in a Series of Five Cases and a Call for Proactive Monitoring.

ABSTRACT: Background/Objectives: Venlafaxine (VEN) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. Arterial hypertension (HTN), heart failure (HF), and arrhythmias are side effects of VEN. Cardiotoxicity (CTOX) as a feature of VEN-associated side-effects has only rarely been described. Methods: We conducted a search of our database for cases of VEN-associated CTOX, analyzing symptoms, echocardiographic findings, and laboratory results. Results: We identified five patients (three females, two males) with VEN-associated CTOX, aged 51 to 87 years at presentation. VEN dose was 150 and 375 mg daily and treatment duration was 1.5 to 15 years. Presenting features were HTN in three, "hypertrophic cardiomyopathy" in two, heart failure in three, and atrial fibr

SUBMITTER: Batusha Sopi B 

PROVIDER: S-EPMC12028038 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature