Clinical Pathologic Profiles of <i>Helicobacter pylori</i> Reveal Age-Specific Peaking with Concomitant Chronic Gastric Inflammation, Robust Immunity, and Tissue Alterations Implying Potential Predisposition to Malignancy in Ha'il, Saudi Arabia.

ABSTRACT: Background/Objectives:Helicobacter pylori (H. pylori) is a significant global health issue causing chronic gastritis, peptic ulcers, and gastric malignancies. Unfortunately, many, particularly in the Middle East, continue to exhibit alarming rates of prevalence. This study aimed to elucidate local epidemiological patterns of H. pylori and examine its histopathological impact on the gastric mucosa. Methods: This retrospective-cross-sectional study included 805 symptomatic adults (329 males, 476 females) who underwent endoscopic evaluation at King Salman Hospital, Ha'il, Saudi Arabia. Biopsies from the antrum and body were processed using routine formalin fixation and paraffin embedding. Staining with hematoxylin-eosin (H&E) and Giemsa permitted assessment

SUBMITTER: Said KB 

PROVIDER: S-EPMC12028268 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature