Unknown

Dataset Information

0

An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds.

ABSTRACT: Disulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis. This approach enabled the efficient synthesis of peptides with the desired disulfide bond connectivities independent of their sequences. Using our strategy, we synthesized five conotoxins, achieving yields of 20-30%. The results demonstrate the potential of our method for synthesizing complex peptides with multiple disulfide bonds.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12028366 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

An Orthogonal Protection Strategy for the Synthesis of Conotoxins Containing Three Disulfide Bonds.

Zhang Hengyu H   Chan Lai Yue LY   Zhang Huanhuan H   Jiang Tao T   Craik David J DJ   Cai Wenqing W   Yu Rilei R  

Marine drugs 20250414 4

Disulfide bonds are crucial for stabilizing bioactive peptides such as conotoxins. We have developed a method for synthesizing conotoxins with three disulfide bonds using Mob, Trt, and Acm protection groups for regionally selective synthesis. This approach enabled the efficient synthesis of peptides with the desired disulfide bond connectivities independent of their sequences. Using our strategy, we synthesized five conotoxins, achieving yields of 20-30%. The results demonstrate the potential of  ...[more]

Similar Datasets

Unknown Characterization of cyclic peptides containing disulfide bonds.
| S-EPMC4608431 | biostudies-literature
Unknown Reverse orthogonal strategy for oligosaccharide synthesis.
| S-EPMC3805137 | biostudies-literature
Unknown Integrated oxidative folding of cysteine/selenocysteine containing peptides: improving chemical synthesis of conotoxins.
| S-EPMC2919336 | biostudies-literature
Unknown A Versatile Disulfide-Containing Solid-Support Strategy for 3'-Modifiers in Oligonucleotides: Introducing Modular Tandem Oligonucleotide Synthesis.
| S-EPMC12392703 | biostudies-literature
Unknown Insights into the Folding of Disulfide-Rich μ-Conotoxins.
| S-EPMC6217517 | biostudies-literature
Unknown General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins.
| S-EPMC7870662 | biostudies-literature
Unknown Oxidative Folding of a Two-Chain Protein Having Three Interchain Disulfide Bonds. Synthesis of Bromelain Inhibitor VI Through Native Chain Assembly.
| S-EPMC12223344 | biostudies-literature
Unknown An Orthogonal Protection Strategy for Synthesizing Scaffold-Modifiable Dendrons and Their Application in Drug Delivery.
| S-EPMC8880417 | biostudies-literature
Transcriptomics Muscleblind-like proteins dimerize by forming disulfide bonds to influence regulation of alternative splicing
2026-03-08 | GSE291521 | GEO
Unknown Amino acid patterns around disulfide bonds.
| S-EPMC3000107 | biostudies-literature