The Role of Resistin in Macrovascular and Microvascular Complications of Type 2 Diabetes.

ABSTRACT: Resistin is an adipokine produced in adipose tissue with pro-inflammatory properties, whose elevation has been associated with insulin resistance and diabetes. Over the past years, significant research has explored the pathophysiological mechanisms involving resistin, utilizing various in vitro and in vivo models. Additionally, numerous clinical studies have aimed to establish a correlation between resistin and the development and progression of macrovascular and microvascular complications in type 2 diabetes. This narrative review summarizes in vitro, in vivo, and human studies published in English since the discovery of resistin in 2001 to the present, examining the role of this adipokine in the pathophysiology of macrovascular and microvascular complications in in vivo and in vitro T2D

SUBMITTER: Reynoso-Roa AS 

PROVIDER: S-EPMC12028410 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature