Reduction in Brain Parenchymal Volume Correlates with Depression and Cognitive Decline in HIV-Positive Males.

ABSTRACT: Background and Objectives: Human immunodeficiency virus (HIV) has a profound impact on the central nervous system (CNS), contributing to cognitive impairment and depressive symptoms even in individuals receiving combination antiretroviral therapy (cART). This study aimed to investigate the associations between brain parenchymal volumes and neuropsychological outcomes, specifically focusing on cognitive function and depressive symptoms in HIV-positive males. Materials and Methods: A total of 48 male participants underwent cognitive assessment using the Mini-Mental State Examination (MMSE), while depressive symptoms were evaluated in 35 participants using the Beck Depression Inventory (BDI). Volumetric brain analysis was conducted through automated imaging software, volBrain (V

SUBMITTER: Peric R 

PROVIDER: S-EPMC12028741 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature