Antimicrobial Investigation of Phthalimide and <i>N</i>-Phthaloylglycine Esters: Activity, Mechanism of Action, Synergism and Ecotoxicity.

ABSTRACT: Motivated by the search for novel antimicrobials against opportunistic resistant pathogens and based on the reported antimicrobial activity of phthalimides, two series of phthalimide and N-phthaloylglycine esters were designed to investigate whether the addition of butyl and aryl groups enhances their antimicrobial properties. Thus, in vitro antimicrobial activity, antifungal mechanism of action, effect combined with Chloramphenicol, in silico/vitro toxicity, and a docking molecular were studied. Phthalimide and N-phthaloylglycine aryl esters were obtained in yields of 75-98%. Phthalimide aryl ester 3b (R = Me) showed the best results against Gram-(+) and Gram-(-) bacteria, S. aureus and P. aeruginosa, respectively, and yeast fungi, C. tropicalis a

SUBMITTER: Alves FS 

PROVIDER: S-EPMC12028801 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature