Proteomic and In Silico Analyses Highlight Complement System's Role in Bladder Cancer Immune Regulation.

ABSTRACT: Background and Objectives: Bladder cancer (BLCA), intimately associated with the immune system, represents a substantial global health burden due to its high recurrence rates and limited therapeutic effectiveness. Although immunotherapy shows promise, challenges persist due to the lack of reliable therapeutic targets. This study aims to investigate potential immune-related biomarkers that could influence the tumor microenvironment in BLCA, using proteomic and in silico approaches. Materials and Methods: Tissue samples from BLCA patients (n = 27) and controls (n = 27) were collected from Şişli Hamidiye Etfal Training and Research Hospital. Proteomic analysis was performed by liquid chromatography/mass spectrometry (LC-MS)/MS to reveal the identities of differentially regulated

SUBMITTER: Korak T 

PROVIDER: S-EPMC12028855 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature