Genetic Interactions of Phase II Xenobiotic-Metabolizing Enzymes <i>GSTO1</i> and <i>GCLC</i> in Relation to Alcohol Abuse and Psoriasis Risk.

ABSTRACT: The present pilot study aimed to investigate whether common single nucleotide polymorphisms (SNPs) in the gene encoding glutathione S-transferase omega 1 (GSTO1), both individually and in combination with variants of the catalytic subunit of the glutamate cysteine ligase (GCLC) gene and environmental risk factors, are associated with the risk of psoriasis. The research included a total of 944 participants, comprising 474 individuals diagnosed with psoriasis and 470 healthy control subjects. Five common SNPs in the GSTO1 gene-specifically, rs11191736, rs34040810, rs2289964, rs11191979, and rs187304410-were genotyped in the study groups using the MassARRAY-4 system. The allele rs187304410-A (OR = 0.19, 95% CI 0.04-0.86, Pperm = 0.02) and the genotype rs187304410-G/A (OR

SUBMITTER: Saranyuk R 

PROVIDER: S-EPMC12028938 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature