New Bioactive Sesquiterpeniods from the Plant-Derived Endophytic Fungus <i>Schizophyllum</i> sp. HM230.

ABSTRACT: Endophytic fungi provide valuable sources for the discovery of secondary metabolites that can be used as lead compounds in drug discovery. In this study, four new sesquiterpenoids with a farnesane backbone, schizophyllol A-B (1-2) and schizophylloside A-B (3-4), together with five known analogues (5-9), were isolated from the plant-derived fungus Schizophyllum sp. HM230. Their structures were established through extensive spectroscopic analyses including HR-ESI-MS and 1D and 2D NMR. The antioxidant activities of all the isolated compounds (compounds 1-9) were evaluated via hydroxyl radical scavenging, DPPH free radical scavenging, and superoxide anion radical scavenging assays. Compounds 1 and 2 displayed stronger

SUBMITTER: Li SY 

PROVIDER: S-EPMC12029045 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature