Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.

ABSTRACT:

Background

Suicide risk is a major concern for patients with major depressive disorder (MDD). Neuroimaging studies have demonstrated that patients with MDD with suicidal ideation or suicide attempt (MDD-S) are accompanied by neurostructural or functional abnormalities, but there is no consensus of opinion on neural substrate alterations involved in MDD-S.

Methods

We performed a whole-brain multimodal meta-analysis of existing magnetic resonance imaging (MRI) studies to identify conjoint and separate alterations of grey matter volume (GMV) and spontaneous brain activity characteristics (regional homogeneity and amplitude of low-frequency fluctuations) between patients with MDD-S and patients with MDD without suicidal ideation or suicidal attempt (MDD-NS) via the seed-based

SUBMITTER: Lin S 

PROVIDER: S-EPMC12029312 | biostudies-literature | 2025 Mar-Apr

REPOSITORIES: biostudies-literature