Bacteriophages Improve the Effectiveness of Rhamnolipids in Combating the Biofilm of <i>Candida albicans</i>.

ABSTRACT: Biofilms formed by Candida albicans pose therapeutic challenges due to their resistance to conventional antimicrobials, highlighting the need for more effective treatments. Rhamnolipids (RLs) are biosurfactants with diverse antimicrobial properties. Bacteriophages are viruses that target specific bacterial strains. Recent studies have shown that they may affect biofilm formation by fungi and yeasts. This study investigated the combined antimicrobial effects of RLs and bacteriophages against C. albicans biofilms, focusing on their anti-adhesive and inhibitory effects on biofilm development. RT-PCR assays were used to analyze gene modulation in C. albicans biofilm formation in response to RLs and bacteriophage treatments, while hyphae formation was examined using microsc

SUBMITTER: Dusza I 

PROVIDER: S-EPMC12029421 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature