Gastrointestinal Microorganisms and Blood Metabolites in Holstein Calves with Different Heat Stress Responses in the Same Hot Environment.

ABSTRACT: This study investigated differences in gastrointestinal microbiota and blood metabolomes in calves with different heat stress (HS) responses in the same hot environment. Ten high (H) and ten low (L) HS response preweaning Holstein calves were selected based on their heat stress level (respiratory rate and rectal temperature), jugular vein blood samples and ruminal and fecal samples were collected. Notable variations were observed in the serum levels of heat shock protein 70 (HSP-70) and IL-2 between the two calf groups (p < 0.05). In group H, rumen and fecal microbiota synergism was disrupted. In the H group, the host metabolome exhibited enrichment in pyruvate metabolism and the tricarboxylic acid cycle (p < 0.05). Key factors bridging the relationship between gastrointestin

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12029475 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature