Comprehensive Genomic Analysis of <i>Klebsiella pneumoniae</i> and Its Temperate N-15-like Phage: From Isolation to Functional Annotation.

ABSTRACT: Antibiotic resistance to Klebsiella pneumoniae poses a major public health threat, particularly in intensive care unit (ICU) settings. The emergence of extensively drug-resistant (XDR) strains complicates treatment options, requiring a deeper understanding of their genetic makeup and potential therapeutic targets. This research delineated an extensively drug-resistant (XDR) Klebsiella pneumoniae strain obtained from an ICU patient and telomeric temperate phage derived from hospital effluent. The bacteria showed strong resistance to multiple antibiotics, including penicillin (≥16 μg/mL), ceftriaxone (≥32 μg/mL), and meropenem (≥8 μg/mL), which was caused by SHV-11 beta-lactamase, NDM-1 carbapenemase, and porin mutations (OmpK37, MdtQ). The strain was categorized

SUBMITTER: Yahya R 

PROVIDER: S-EPMC12029707 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature