Uncovering Non-Invasive Biomarkers in Paediatric Severe Acute Asthma Using Targeted Exhaled Breath Analysis.

ABSTRACT:

Background

Severe acute asthma (SAA) in children can be life-threatening. There has been a significant rise in paediatric intensive care unit (PICU) admissions due to SAA over the past two decades. While asthma is a heterogeneous disease, its underlying pathophysiological pathways remain underexplored. This study aimed to assess the value of non-invasive targeted exhaled breath metabolomics analysis to better characterise SAA.

Methods

Breath samples from 17 children admitted to the PICU with SAA (cases) and 27 children with controlled severe asthma (controls) were analysed using thermal desorption gas chromatography-mass spectrometry (TD-GC-MS).

Results

A targeted volatile organic compound (VOC) analysis identified 25 compounds, of which 16 were shared between groups.

SUBMITTER: van den Berg S 

PROVIDER: S-EPMC12029713 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature