Plasma and Urine Metabolites Associated with Microperimetric Retinal Sensitivity in Age-Related Macular Degeneration.

ABSTRACT:

Background

Best-corrected visual acuity (BCVA) is the current gold standard of retinal function measurement but is not affected in early and intermediate forms of age-related macular degeneration (AMD). Increasing evidence suggests that microperimetry is a sensitive measure of visual function. This study sought to analyze the associations between plasma and urine metabolites and microperimetry in AMD.

Methods

We included data on 363 eyes (95 controls, 268 AMD). Microperimetry was performed in patients with or without AMD using the Macular Integrity Assessment (MAIA) microperimetry system, employing a 37-point full-threshold protocol. Plasma and urine samples were analyzed via ultra-high-performance liquid chromatography-mass spectrometry. Multilevel mixed-effects linear mode

SUBMITTER: Sourirajan K 

PROVIDER: S-EPMC12029753 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature