Role of <i>Thymus ciliatus</i> (Thyme) to Ameliorate the Acute Neurotoxicity Induced by Bisphenol A: <i>In Vivo</i> Supported with Virtual Study.

ABSTRACT: Background/Objectives: The purpose of this research was to investigate the effects of bisphenol A (BPA) exposure on neurobehavioral testing in young Wistar rats and to evaluate the therapeutic potential of Thymus ciliatus (TEO) essential oil to attenuate the damage induced by this chemical toxin. Methods: The essential oil was extracted by hydro-distillation (yield of 2.26%), and the characterization by GC-MS indicates that the major components of Thymus ciliatus oil are thymol (63.33%), p-cymene (13.4%), and σ-terpinene (6.69%). Acute BPA intoxication was induced with a dose of 50 mg/kg orally for 60 days. The neurobehavioral evaluation, performed using a comprehensive set of tests including the forced swim test, dark/light box, Morris water maze, open field te

SUBMITTER: Kourat D 

PROVIDER: S-EPMC12030012 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature