Mutational Analysis of Colistin-Resistant <i>Pseudomonas aeruginosa</i> Isolates: From Genomic Background to Antibiotic Resistance.

ABSTRACT: This study analyzed eleven isolates of colistin-resistant Pseudomonas aeruginosa, originating from Portugal and Taiwan, which are associated with various pathologies. The results revealed significant genetic diversity among the isolates, with each exhibiting a distinct genetic profile. A prevalence of sequence type ST235 was observed, characterizing it as a high-risk clone, and serotyping indicated a predominance of type O11, associated with chronic respiratory infections in cystic fibrosis (CF) patients. The phylogenetic analysis demonstrated genetic diversity among the isolates, with distinct clades and complex evolutionary relationships. Additionally, transposable elements such as Tn3 and IS6 were identified in all isolates, highlighting their importance in the mobility of antibi

SUBMITTER: De Sousa T 

PROVIDER: S-EPMC12030098 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature