Silver Nanoparticles Decorated UiO-66-NH₂ Metal-Organic Framework for Combination Therapy in Cancer Treatment.

ABSTRACT: Background: Nanomedicine has shown significant promise in advancing cancer diagnostics and therapeutics. In particular, nanoparticles (NPs) offer potential for overcoming limitations associated with conventional therapies, such as off-target toxicity and side effects. Among the various NPs, silver nanoparticles (AgNPs) have garnered attention due to their cytotoxic and genotoxic properties in cancer cells. However, despite their potential, the optimization of AgNPs efficacy often necessitates combination strategies with other therapeutic agents. This study explores the potential of AgNPs integrated with Zr-based metal-organic frameworks (MOFs) UiO-66 for drug delivery, to enhance cancer therapy. Methods: We decorated amino-terephthalic based UiO-66-NH₂ with AgNPs a

SUBMITTER: Ragonese F 

PROVIDER: S-EPMC12030114 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature