TOTUM-854 Human Circulating Bioactives Preserve Endothelial Cell Function.

ABSTRACT: Background: TOTUM-854 is a patented plant extract blend characterized by its components that have previously been described for their potential health benefits in limiting hypertension onset. However, most of the literature data remain descriptive regarding the mode of action at the cellular level, especially in humans, and further investigations are required for optimized therapeutic strategies. Methods: We first demonstrated in an L-NAME mouse model that TOTUM-854 supports the prevention of hypertension in vitro and in vivo. Then, we designed an ex vivo clinical innovative approach considering the circulating metabolites produced by the digestive tract upon TOTUM-854 ingestion in humans. Human serum was collected in healthy volunteers before and after the acute intake of 3.

SUBMITTER: Wauquier F 

PROVIDER: S-EPMC12030166 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature