Kinin B₁ Receptor Agonist Enhances Blood-Brain Barrier Permeability in Healthy and Glioblastoma Environments.

ABSTRACT: Background/Objectives: The low permeability of the blood-brain barrier (BBB) represents a significant challenge to effective systemic chemotherapy for primary and metastatic brain cancers. Kinin receptors play a crucial role in modulating BBB permeability, and their agonist analogs have been explored in preclinical animal models to enhance drug delivery to the brain. In this study, we investigated whether des-Arg⁹-bradykinin (DBK), a physiological agonist of kinin B₁ receptor (B1R), acts as a brain drug delivery adjuvant by promoting the transient opening of the BBB. Methods: Human brain microvascular endothelial cells (HBMECs) were treated with DBK in the culture medium and in conditioned media from glioblastoma cell lines, namely T98G (CMT98G) and U87M

SUBMITTER: Batista C 

PROVIDER: S-EPMC12030169 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature