Microvascular angiotensin II type 2 receptor function is enhanced in young females and declines in a model of murine aging.

ABSTRACT:

Introduction

Angiotensin II (AngII) affects cardiovascular health, mediating impacts through AngII type 1 (AT1R) and type 2 (AT2R) receptors. The present study investigated sex and aging-related differences in microvascular AngII receptor function in mice and humans.

Methods

Mesenteric resistance arteries (MRA) were isolated from 3-, 12-, and 18-month-old female and male C57/Bl6 mice. Wire myography was used to measure vasoconstriction to AngII and vasodilation to an AT2R agonist (compound 21, C21). Seven healthy adults (3 premenopausal women and 4 age-matched men) were recruited to participate in a study measuring cutaneous microvascular vasoconstriction to AngII in the presence and absence of 10 μM PD123319, an AT2R antagonist.

Results

In murine MRA, AngII-induced c

SUBMITTER: Turner CG 

PROVIDER: S-EPMC12030185 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature