The Relationship between Visceral Fat Accumulation and Risk of Cardiometabolic Multimorbidity: The Roles of Accelerated Biological Aging.

ABSTRACT:

Objectives

To investigate the association between visceral fat accumulation and the risk of cardiometabolic multimorbidity (CMM) and the potential roles of accelerated biological aging in this relationship.

Methods

Using data from the UK Biobank, a nationwide cohort study was conducted using the available baseline body roundness index (BRI) measurement. Biological aging was assessed using the Klemera-Doubal method for biological age and the phenotypic age algorithms. The association between the BRI and CMM was estimated using the Cox proportional hazards regression model, while the roles of biological aging were examined through interaction and mediation analyses.

Results

During a median follow-up of 14.52 years, 6156 cases of CMM were identified. A significant associ

SUBMITTER: Zhu T 

PROVIDER: S-EPMC12030224 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature