The Protective Effect of FOXO3 rs2802292 G-Allele on Food Intake in a Southern Italian Cohort Affected by MASLD.

ABSTRACT: Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a cluster of conditions characterized by accumulations of fat, metabolic factors such as obesity, diabetes and high cholesterol. MASLD is now the leading cause of chronic liver disease worldwide, with a rapidly increasing trend. We aimed to demonstrate that genetic variants of rs2802292 SNP can influence the development of MASLD even after many years. Methods: We studied 650 participants from the NUTRIHEP cohort, both at baseline (2005-2006) and at first recall (2014-2018), and genotyped rs2802292. The validated European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire was administered during the visit, and each single food was assigned to one of 33 groups. Results:

SUBMITTER: Donghia R 

PROVIDER: S-EPMC12030307 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature