Oral Vaccination with Attenuated <i>Salmonella</i> Expressing Viral M25 Protein Effectively Protects Mice Against Murine Cytomegalovirus Infection.

ABSTRACT: Attenuated Salmonella strains are promising oral vectors for vaccination against human infectious diseases. Human cytomegalovirus (CMV) is among the most common causes of disability in children, including intellectual disability and sensorineural hearing loss. Developing an anti-CMV vaccine is a major public health priority. We report in this study the construction of a new attenuated Salmonella strain to express murine cytomegalovirus (MCMV) M25 protein and its use for vaccination in mice against MCMV infection. In mice orally vaccinated with the constructed Salmonella vector carrying the M25 expression cassette, we revealed a substantial induction of anti-MCMV serum IgG and mucosal IgA humoral responses and a considerable elicitation of anti-MCMV T cell responses. Wh

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12030445 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature