Comprehensive Studies on the Regulation of Type 2 Diabetes by Cucurbitane-Type Triterpenoids in <i>Momordica charantia</i> L.: Insights from Network Pharmacology and Molecular Docking and Dynamics.

ABSTRACT: Background/Objectives:Momordica charantia L. (M. charantia), a widely cultivated and frequently consumed medicinal plant, is utilized in traditional medicine. Cucurbitane-type triterpenoids, significant saponin components of M. charantia, exhibit hypoglycemic effects; however, the underlying mechanisms remain unclear. Methods: This study utilized comprehensive network pharmacology to identify potential components of M. charantia cucurbitane-type triterpenoids that may influence type 2 diabetes mellitus (T2DM). Additionally, molecular docking and molecular dynamics studies were performed to assess the stability of the interactions between the selected components and key targets. Results: In total, 22 candidate active components of M. chara

SUBMITTER: Niu Y 

PROVIDER: S-EPMC12030615 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature