Albaconazole Polymeric Nanocapsules for Treating <i>Trypanosoma cruzi</i> Infections.

ABSTRACT: The therapeutic management of Chagas disease requires new medicines because the standard-of-care drugs available induce adverse effects and have limited efficacy. In this study, we developed a formulation of albaconazole (ABZ) loaded in biodegradable polymeric nanocapsules (NCs). Free ABZ and ABZ-loaded NCs were similarly active against the Y strain and inactive against the Colombian strain epimastigotes of Trypanosoma cruzi. Infected mice were given ABZ in different doses and treatment schedules by oral, SC, and IM routes during the acute phase of infection. Free ABZ taken orally reduced parasitemia and suppressed mortality; however, all the animals maintained patent parasitemia during and after treatment. ABZ-NCs increased anti-T. cruzi effects (p < 0.05), inducing n

SUBMITTER: de Barros CM 

PROVIDER: S-EPMC12030734 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature