Rotenone Exposure During Development Conditions Parkinsonian Phenotype in Young Adult Rats.

ABSTRACT: Current studies suggest that environmental toxins may play a significant role in the fetal origins of Parkinson's disease (PD). Significant evidence from animal experiments has demonstrated that these toxins can disrupt fetal neurodevelopment. PD is a neurodegenerative disorder related to the loss of dopaminergic neurons in the substantia nigra pars compacta (S. nigra) and accumulation of α-synuclein (α-syn) in the brain. Parkinson's disease has long been associated with an idiopathic etiology, with environmental or ontogenetic factors as causes; however, the list of causal agents continues to expand as their effects are investigated at different stages of development. To explore the potential ontogenetic origins of PD, we exposed female rats subcutaneously (s.c.) to 1 mg/kg of the

SUBMITTER: Gomez-Chavarin M 

PROVIDER: S-EPMC12030936 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature