Assessing the Utility of Broad-Acting Inhibitors as Therapeutics in Diverse Venoms.

ABSTRACT: Examination of venom constituent bioactivities from diverse venomous animals shows certain highly conserved classes, including enzymes (e.g., phospholipases and metalloproteinases) and pore-forming proteins. While antivenoms targeting other unique and lethal venom components have proven to be life-saving, venom-enzyme-driven tissue damage and morbidity persists. Broad-acting enzyme inhibitors demonstrate the potential to augment antivenom approaches. In this study, we investigate the potential utility of certain broad-acting inhibitors in cubozoa for the first time. Fluorogenic assays were used to determine the phospholipase A₂ (PLA₂) and matrix metalloproteinase (MMP) activity of the Hawaiian box jellyfish, Alatina alata, and this was compared to representativ

SUBMITTER: Kadler R 

PROVIDER: S-EPMC12031005 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature